Reference architectures: overview
Last reviewed: 2026-06-28 — see the freshness policy.
Learning objectives
After this chapter you will be able to:
- Read the case studies in this part as worked, end-to-end SA deliverables.
- Use a consistent structure to document any reference architecture.
- Map each case study to the concepts and labs earlier in the bootcamp.
What this part is
Parts 1–8 taught the building blocks. This part puts them together into five worked reference architectures — the kind of artifact an SA produces and defends. Each is a complete solution to a realistic brief, not a feature tour, and each links to a hands-on lab.
How each case study is structured
Every case study follows the same SA deliverable shape — the structure you should reuse for your own designs and the capstone:
- Problem & context — the business problem and who has it.
- Requirements (NFRs) — the measurable bar (security, latency, availability, compliance, cost).
- Architecture — the design, as a C4-style diagram.
- Key decisions & trade-offs — the ADRs: what was chosen and what was given up.
- Compliance mapping — which controls satisfy which regime.
- Cost — the TCO shape.
- Lab — where to build it.
The five case studies
flowchart TB
FHIR["FHIR interoperability platform<br/>(Parts 2, 3, 8)"]
RWD["RWD lakehouse on OMOP<br/>(Parts 2, 3, 5)"]
RAG["Clinical RAG assistant<br/>(Parts 3, 4, 6)"]
Agent["Agentic AI assistant<br/>(Parts 2, 6)"]
Gen["Genomics pipeline<br/>(Parts 3, 4, 7)"]
| Case study | Brings together | Lab |
|---|---|---|
| FHIR interoperability platform | HL7v2/FHIR, HIPAA, EHR integration | hls-fhir-interop |
| RWD lakehouse | OMOP, lakehouse, governance, RWE | hls-lakehouse-rwd |
| Clinical RAG | GCP/Vertex, RAG, PHI boundary | RAGonGCP |
| Agentic AI assistant | Bedrock agents, tools, guardrails | aws-health-agents |
| Genomics pipeline | Sequencing, HealthOmics, variant stores | RNASEQ |
Read them as exemplars: the value is in why each decision was made and what it traded — that reasoning is the SA craft this bootcamp builds.
Check yourself
- What seven sections make up a reference-architecture write-up here, and why does "trade-offs" matter as much as the diagram?
- Which earlier parts does the RWD lakehouse case study draw on?
- Why are these framed as worked deliverables rather than product tours?